PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma
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منابع مشابه
PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma.
BACKGROUND Approximately 30% of all colorectal cancer (CRC) patients are diagnosed with stage II disease. Adjuvant therapy is not widely recommended. However, it is well established that a subgroup of patients with stage II are at high risk for recurrence within their lifetime and should be considered for adjuvant chemotherapy. The present work was designed to assess the value of group IIA phos...
متن کاملPLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid))
Description Background: The phospholipase A2 (PLA2s) superfamily, consisting of at least 34 members subdivided into at least 15 groups, is a group of intracellular and secreted enzymes that hydrolyzes the sn-2 ester bond in glycerophospholipids found in lipoproteins and cellular membranes to liberate fatty acids and lysophospholipids that can act as intracellular second messengers or are furthe...
متن کاملSimplified YM-26734 inhibitors of secreted phospholipase A2 group IIA.
Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A(2) (sPLA(2)) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.
متن کاملLipoprotein-associated phospholipase A2 (Lp-PLA2)
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متن کاملLipoprotein-associated phospholipase A2 (Lp-PLA2)
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2009
ISSN: 0923-7534
DOI: 10.1093/annonc/mdn783